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{\flominor\f31553\fbidi \froman\fcharset177\fprq2 Times New Roman (Hebrew);}{\flominor\f31554\fbidi \froman\fcharset178\fprq2 Times New Roman (Arabic);}{\flominor\f31555\fbidi \froman\fcharset186\fprq2 Times New Roman Baltic;}
{\flominor\f31556\fbidi \froman\fcharset163\fprq2 Times New Roman (Vietnamese);}{\fdbminor\f31560\fbidi \froman\fcharset0\fprq2 Yu Mincho Western;}{\fdbminor\f31558\fbidi \froman\fcharset238\fprq2 Yu Mincho CE;}
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{\fbiminor\f31581\fbidi \froman\fcharset161\fprq2 Times New Roman Greek;}{\fbiminor\f31582\fbidi \froman\fcharset162\fprq2 Times New Roman Tur;}{\fbiminor\f31583\fbidi \froman\fcharset177\fprq2 Times New Roman (Hebrew);}
{\fbiminor\f31584\fbidi \froman\fcharset178\fprq2 Times New Roman (Arabic);}{\fbiminor\f31585\fbidi \froman\fcharset186\fprq2 Times New Roman Baltic;}{\fbiminor\f31586\fbidi \froman\fcharset163\fprq2 Times New Roman (Vietnamese);}}
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\par }\pard \ltrpar\qc \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab \tab \tab \tab 
\par }\pard \ltrpar\qj \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'40\'81\'40\'81\'40\'81\'40}{\rtlch\fcs1 \af11 
\ltrch\fcs0 \expnd15\expndtw75\kerning0\fittext1680\insrsid9133080\charrsid11741512 \loch\af21\hich\af21\dbch\f11 \'8a\'77\'88\'ca\'8b\'4c\'94\'d4}{\rtlch\fcs1 \af11 \ltrch\fcs0 \expnd3\expndtw15\kerning0\fittext-1\insrsid9133080\charrsid11741512 
\loch\af21\hich\af21\dbch\f11 \'8d\'86}{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid3213177 \hich\af21\dbch\af11\loch\f21       }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'98\'5f\'81\'40\'81\'40\'91\'e6\'81\'40\'81\'40
\'81\'40\'81\'96\'81\'40\'81\'40\'81\'40\'81\'40\'8d\'86}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 
\par }\pard \ltrpar\qc \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab \tab \tab \tab 
\par }\pard \ltrpar\qj \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'40\'81\'40\'81\'40\'81\'40}{\rtlch\fcs1 \af11 
\ltrch\fcs0 \expnd3\expndtw15\kerning0\fittext1680\insrsid9133080\charrsid11741512 \loch\af21\hich\af21\dbch\f11 \'8a\'77\'88\'ca\'8e\'f6\'97\'5e\'82\'cc\'93\'fa\'95\'74}{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid3213177 \hich\af21\dbch\af11\loch\f21       }{
\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid6635685 \loch\af21\hich\af21\dbch\f11 \'97\'df\'98\'61}{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'40\'81\'96\'81\'40\'94\'4e\'81\'40\'81\'40\'81\'40\'8c\'8e\'81\'40\'81\'40
\'81\'40\'93\'fa}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 
\par }\pard \ltrpar\qc \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab \tab \tab \tab 
\par }\pard \ltrpar\qj \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'40\'81\'40\'81\'40\'81\'40}{\rtlch\fcs1 \af11 
\ltrch\fcs0 \expnd3\expndtw15\kerning0\fittext1680\insrsid9133080\charrsid11741512 \loch\af21\hich\af21\dbch\f11 \'8a\'77\'88\'ca\'8e\'f6\'97\'5e\'82\'cc\'97\'76\'8c\'8f}{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid3213177 \hich\af21\dbch\af11\loch\f21       }{
\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'8a\'77\'88\'ca\'8b\'4b\'91\'a5\'91\'e6\'82\'53\'8f\'f0\'91\'e6\'82\'51\'8d\'80\'8a\'59\'93\'96}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 
\par }\pard \ltrpar\qc \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab \tab \tab \tab 
\par }\pard \ltrpar\qj \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'40\'81\'40\'81\'40\'81\'40}{\rtlch\fcs1 \af11 
\ltrch\fcs0 \expnd6\expndtw30\kerning0\fittext1680\insrsid9133080\charrsid11741512 \loch\af21\hich\af21\dbch\f11 \'8a\'77\'88\'ca\'98\'5f\'95\'b6\'91\'e8}{\rtlch\fcs1 \af11 \ltrch\fcs0 \expnd12\expndtw60\kerning0\fittext-1\insrsid9133080\charrsid11741512 
\loch\af21\hich\af21\dbch\f11 \'96\'da}{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid3213177 \hich\af21\dbch\af11\loch\f21       }{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid9133080 \hich\af21\dbch\af11\loch\f21 Familial essential thrombocythemia associated with 

\par }\pard \ltrpar\qc \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab \tab \tab \tab \tab \tab \tab \tab 
\par }\pard \ltrpar\qj \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3213177 \tab \tab \tab }{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid3213177 
\hich\af21\dbch\af11\loch\f21       }{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid9133080 \hich\af21\dbch\af11\loch\f21 a dominnant-positive activating mutation of c-MPL}{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'40}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 
\par }\pard \ltrpar\qc \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab \tab \tab \tab \tab \tab \tab \tab 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3213177 \tab \tab \tab }{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid3213177 \hich\af21\dbch\af11\loch\f21    }{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid9133080 \hich\af21\dbch\af11\loch\f21 
gene,which encodes for the receptor for thrombopointuin\tab \tab \tab \tab \tab \tab \tab \tab \tab \tab 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab \tab \tab }{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid3213177 \hich\af21\dbch\af11\loch\f21   }{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid9133080 \hich\af21\dbch\af11\loch\f21 (}{\rtlch\fcs1 \af11 \ltrch\fcs0 
\insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'83\'67\'83\'8d\'83\'93\'83\'7b\'83\'7c\'83\'47\'83\'60\'83\'93\'8e\'f3\'97\'65\'91\'cc\'82\'c5\'82\'a0\'82\'e9}{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid9133080 \hich\af21\dbch\af11\loch\f21 c-MPL}{\rtlch\fcs1 
\af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'88\'e2\'93\'60\'8e\'71\'82\'cc\'8a\'88\'90\'ab\'89\'bb}{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid3213177 \loch\af21\hich\af21\dbch\f11 \'95\'cf\'88\'d9}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9133080 \tab \tab \tab \tab 
\par }\pard \ltrpar\qj \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3213177 \tab \tab \tab }{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid3213177 
\hich\af21\dbch\af11\loch\f21     }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'40\'82\'c9\'82\'e6\'82\'e9\'89\'c6\'91\'b0\'90\'ab\'8c\'8c\'8f\'ac\'94\'c2\'8c\'8c\'8f\'c7\'81\'6a}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9133080 \tab \tab \tab \tab \tab \tab \tab \tab \tab \tab \tab \tab 
\par }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'40\'81\'40\'81\'40\'81\'40}{\rtlch\fcs1 \af11 \ltrch\fcs0 \expnd6\expndtw30\kerning0\fittext1680\insrsid9133080\charrsid11741512 \loch\af21\hich\af21\dbch\f11 \'98\'5f
\'95\'b6\'90\'52\'8d\'b8\'88\'cf}{\rtlch\fcs1 \af11 \ltrch\fcs0 \expnd12\expndtw60\kerning0\fittext-1\insrsid9133080\charrsid11741512 \loch\af21\hich\af21\dbch\f11 \'88\'f5}{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid3213177 \loch\af21\hich\af21\dbch\f11 
\'81\'40\'81\'40\'81\'40}{\rtlch\fcs1 \af11 \ltrch\fcs0 \f11\insrsid9133080\charrsid9133080 \hich\af11\dbch\af11\loch\f11 (}{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'8e\'e5\'81\'40\'81\'40\'8d\'b8\'81\'6a}{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid9133080 \tab }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'96}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 
\'81\'40\'81\'40\'8b\'b3\'8e\'f6}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab \tab 
\par 
\par }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid3213177 \loch\af21\hich\af21\dbch\f11 \'81\'40\'81\'40\'81\'40\'81\'40\'81\'40\'81\'40\'81\'40\'81\'40\'81\'40\'81\'40\'81\'40\'81\'40}{\rtlch\fcs1 \af21 \ltrch\fcs0 \insrsid3213177 \hich\af21\dbch\af11\loch\f21  }{
\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid3213177 \loch\af21\hich\af21\dbch\f11 \'81\'40\'81\'40\'81\'69}{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'95\'9b\'81\'40\'81\'40\'8d\'b8\'81\'6a}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid9133080 \tab }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'96}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'40\'81\'40
\'8b\'b3\'8e\'f6}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'96}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 
\loch\af21\hich\af21\dbch\f11 \'8b\'b3\'8e\'f6}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 
\par }\pard \ltrpar\qc \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9133080 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 
\par 
\par 
\par \tab }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9133080 \loch\af21\hich\af21\dbch\f11 \'81\'69\'92\'8d\'81\'6a\'81\'96\'82\'cd\'8b\'4c\'93\'fc\'82\'b5\'82\'c8\'82\'a2}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9133080 \tab \tab \tab \tab \tab \tab \tab }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9201855 
\par }\pard \ltrpar\qc \li0\ri0\nowidctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid9201855 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9201855 \page }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9201855 \loch\af21\hich\af21\dbch\f11 
\'98\'5f\'81\'40\'81\'40\'95\'b6\'81\'40\'81\'40\'93\'e0\'81\'40\'81\'40\'97\'65\'81\'40\'81\'40\'82\'cc\'81\'40\'81\'40\'97\'76\'81\'40\'81\'40\'8e\'7c}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9201855 
\par 
\par 
\par }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9201855 \loch\af21\hich\af21\dbch\f11 \'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\loch\af21\hich\af21\dbch\f11 \'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45
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\par 
\par }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9201855 \loch\af21\hich\af21\dbch\f11 \'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45
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\par 
\par }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9201855 \loch\af21\hich\af21\dbch\f11 \'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45\'81\'45
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\par 
\par 
\par }{\rtlch\fcs1 \af11 \ltrch\fcs0 \insrsid9201855 \loch\af21\hich\af21\dbch\f11 \'81\'69\'92\'8d\'81\'6a\'98\'61\'95\'b6\'82\'c5\'82\'51\'81\'43\'82\'4f\'82\'4f\'82\'4f\'8e\'9a\'88\'c8\'93\'e0\'82\'c5\'82\'dc\'82\'c6\'82\'df\'82\'e9}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid9201855 \tab \tab \tab \tab \tab \tab }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11013672 
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