Multilevel Biofunctional Analytics
Staffs
Hirokazu Yagi, Ph.D., Associate Professor
Research Project
- Glycobiology: Exploring the Role of glycans in Neurology, Immunology, Cancer, and Viral Infections
- Understanding the network of biomolecules using omics analysis
Living organisms are complex systems composed of a variety of biological substances such as nucleic acids, proteins, lipids, and glycans, which work together to perform various biological functions. Our laboratory employs an omics approach that focuses on the glycome and proteome to understand the network of molecular information that constitutes biological systems. We aim to decipher the functions of biomolecules constituting such networks, from the molecular to the cellular and in vivo levels, in a multilevel biofunctional analysis that employs techniques from structural biology, biochemistry, and cell biology.
(1)Glycan structure-function analysis and drug discovery
Glycans are involved in many biological phenomena such as cell-cell interactions, immune responses, and cancer progression. However, due to their structural complexity and diversity, predicting the structure of glycans and regulating their expression is challenging. Our laboratory aims to understand the biosynthesis system of glycans and decode the biological information carried by glycans using a glycan structural analysis approach. Additionally, we are actively involved in developing drugs that target glycans.
Glycans are involved in many biological phenomena such as cell-cell interactions, immune responses, and cancer progression. However, due to their structural complexity and diversity, predicting the structure of glycans and regulating their expression is challenging. Our laboratory aims to understand the biosynthesis system of glycans and decode the biological information carried by glycans using a glycan structural analysis approach. Additionally, we are actively involved in developing drugs that target glycans.
(2) Elucidation of biomolecular networks using omics analysis
Our laboratory is also focused on elucidating biomolecular networks using omics analysis. By using glycome and proteome omics technologies, we aim to understand the network of biomolecules that constitute biological systems. We integrate this information as an information network spanning multiple omics hierarchies to deepen our understanding of the entire biological system. This integrated approach enables us to develop new biomarkers and drugs that can be used for diagnosis and treatment of various diseases.
Our laboratory is also focused on elucidating biomolecular networks using omics analysis. By using glycome and proteome omics technologies, we aim to understand the network of biomolecules that constitute biological systems. We integrate this information as an information network spanning multiple omics hierarchies to deepen our understanding of the entire biological system. This integrated approach enables us to develop new biomarkers and drugs that can be used for diagnosis and treatment of various diseases.
Contact Information
Hirokazu Yagi
Graduate School of Pharmaceutical Sciences, Nagoya City University,
3-1, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
E-mail:hyagi@phar.nagoya-cu.ac.jp
TEL:+81-52-836-3448/FAX: +81-52-836-3450
Graduate School of Pharmaceutical Sciences, Nagoya City University,
3-1, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
E-mail:hyagi@phar.nagoya-cu.ac.jp
TEL:+81-52-836-3448/FAX: +81-52-836-3450